We presently have one PhD vacancy for an international student. We can only consider applications from academically outstanding students who have, or expect to obtain, a scholarship from their home country.
Postgraduate Research Profile Faculty of Life Sciences: Wenxia Qin
PhD Position Available
The molecular basis of metastatic Breast Cancer
Principal Investigators: Dr Paul Shore
Project available for individuals with self arranged funding.
Metastatic Breast Cancer is incurable. There is therefore an urgent need to develop therapies to prevent metastatic breast cancer. Our previous work has demonstrated that the Runx2 transcriptional co-activator, CBFb, is required for the expression of metastatic genes in breast cancer cells. The aim of this project is to determine the role of CBFb, in the formation of metastases and identify new therapeutic targets to prevent metastasis. The project uses ChIP-seq, RNA-seq and microarray technologies combined with novel 3-D cell co-culture systems to identify genes that promote metastasis in breast cancer.
- Mendoza-Villanueva, D., Zeef, L. & Shore, P (2011). Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFbeta-dependent expression of the Wnt antagonist, Sclerostin.Breast Cancer Res, 13(5), R106.
- Deng W, Lopez-Camacho C Tang J-Y, Mendoza-Villanueva D, Maya-Mendoza, Jackson D.A, and Shore P. (2012). Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription. PNAS 109 (5), 1524.
- Mendoza-Villanueva D, Deng W, Lopez-Camacho C, Shore P. (2010). The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells. Molecular Cancer, 9(171),
- Shore P. (2005). A role for Runx2 in normal mammary gland and breast cancer bone metastasis. Journal of cellular biochemistry, 96(3), 484-9.
- Inman CK, Li N, Shore P. (2005). Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. Molecular and Cellular Biology, 25(8), 3182-93.
This project has a Band 3 fee. Details of different fee bands are available for UK/EU or International applicants. See: Fees.
How to Apply
Find out How to apply for this PhD Project.
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