Vacancies

reducedspacelogoWe presently have one PhD vacancy for an international student. We can only consider applications from academically outstanding students who have, or expect to obtain, a scholarship from their home country.

 

Postgraduate Research Profile Faculty of Life Sciences: Wenxia Qin

PhD Position Available

The molecular basis of metastatic Breast Cancer

Principal Investigators: Dr Paul Shore

Funding

Project available for individuals with self arranged funding.

Description

Metastatic Breast Cancer is incurable. There is therefore an urgent need to develop therapies to prevent metastatic breast cancer. Our previous work has demonstrated that the Runx2 transcriptional co-activator, CBFb, is required for the expression of metastatic genes in breast cancer cells. The aim of this project is to determine the role of CBFb, in the formation of metastases and identify new therapeutic targets to prevent metastasis. The project uses ChIP-seq, RNA-seq and microarray technologies combined with novel 3-D cell co-culture systems to identify genes that promote metastasis in breast cancer.

Related Publications

  • Mendoza-Villanueva, D., Zeef, L. & Shore, P (2011). Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFbeta-dependent expression of the Wnt antagonist, Sclerostin.Breast Cancer Res, 13(5), R106.
  • Deng W, Lopez-Camacho C Tang J-Y, Mendoza-Villanueva D, Maya-Mendoza, Jackson D.A, and Shore P. (2012). Cytoskeletal protein filamin A is a nucleolar protein that suppresses ribosomal RNA gene transcription. PNAS 109 (5), 1524.
  • Mendoza-Villanueva D, Deng W, Lopez-Camacho C, Shore P. (2010). The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells. Molecular Cancer, 9(171),
  • Shore P. (2005). A role for Runx2 in normal mammary gland and breast cancer bone metastasis. Journal of cellular biochemistry, 96(3), 484-9.
  • Inman CK, Li N, Shore P. (2005). Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. Molecular and Cellular Biology, 25(8), 3182-93.

Fee Band

This project has a Band 3 fee. Details of different fee bands are available for UK/EU or International applicants. See: Fees.

How to Apply

Find out How to apply for this PhD Project.

Why Manchester?

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Manchester Town Hall

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Media City Manchester

With over 350 postgraduates in Life Sciences the Faculty is one of the largest and most diverse research environments in the UK.  Manchester is a vibrant city, with activities to suit all interests. With a huge choice of restaurants, bars, shops, sports facilities and museums, all within easy reach of the campus, you will never struggle to find ways in which to occupy your spare time. All of this, combined with your postgraduate studies, will no doubt provide you with a fulfilling graduate experience. Travelling in and around the city is easy, with buses and trams connecting all major hotspots, as well as having the beautiful Peak District National park on our doorstep.